个人简介

鞠斌，研究员，博士生导师，疑难重症及罕见病全国重点实验室独立PI。曾获中华医学科技奖、中国免疫学会青年学者奖、深圳市青年科技奖、深圳市科技进步奖等。获得国自然优秀青年基金、国自然重大研究计划集成项目、国家科技重大专项课题、广东省杰出青年基金、深圳市优秀青年基金等项目资助。院校引进人才。

主要研究内容

长期从事抗病毒中和抗体研究，以多种急性/慢性病毒感染为模型，紧密围绕病毒感染与抗体中和的几个博弈阶段，系统阐明了抗体如何对抗病毒感染及其发挥作用的分子机制。以第一/通讯作者（含共同）发表SCI论文30余篇，包括Cell, Nature, Nat Immunol, Immunity, Gut, PLoS Pathog, Cell Res, Cell Rep, Sci Adv, Nat Commun等；以共同发明人授权专利10余项，获批新冠病毒中和抗体联合药物安巴韦/罗米司韦单抗注射液等。

代表性成果

1.Ju Bin^(#)(*), Liu Zhouqing^(#), Yan Hu^(#), Liu Yong^(#), Zhang Lu^(#), Ge Xiangyang^(#), Wang Xin^(#), Si Zhu, Zhou Bing, Fan Qing, Wang Miao, Li Yuxiao, Lai Wenlong, Gan Jianhui, Wang Haiyan, Zhao Juanjuan, Xia Yuchen^(*), Liao Maofu^(*), Zhang Zheng^(*). Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer . Gut, 2026, doi: 10.1136/gutjnl-2025-336641. (IF=""25.3)

2.Li Wenting^(#), Liu Congcong^(#), Li Yaning^(#), Gui Qi^(#), Cheng Lin, Fan Qing, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng^(*), Yan Renhong^(*), Ju Bin^(*). A SARS-CoV-2 variant-induced NTD-targeting antibody enhances viral infection via a distinctive binding mode . PLoS Pathogens, 2026, 22(2):e1013828. (IF=""5.4)

3.Ju Bin^(#)(*), Liu Congcong^(#), Zhang Jingjing^(#), Li Yaning^(#), Yang Haonan^(#), Zhou Bing^(#), Huang Baoying^(#), Ma Jianrong, Lu Jiahan, Cheng Lin, Cong Zhe, Zhu Lin, Shi Tianhao, Sun Yuehong, Li Na, Chen Ting, Wang Miao, Tang Shilong, Ge Xiangyang, Zhao Juanjuan, Tan Wen-Jie^(*), Yan Renhong^(*), Xue Jing^(*), Zhang Zheng^(*). Structurally conserved human anti-A35 antibodies protect mice and macaques from mpox virus infection . Cell, 2025, 188(22):6253-6265. (IF=""48.9)

4.Yan Hu^(#), Liu Congcong^(#), Li Yuxiao^(#), Tang Shilong, Guo Huimin, Zhou Bing, Fan Qing, Wang Haiyan, Ge Xiangyang, Wang Xin, Liao Xuejiao, Li Jin, Zhang Zheng^(*), Ju Bin^(*). The characterization and structural basis of a human broadly binding antibody to HBV core protein . Journal of Virology, 2025, 99(1):e0169424. (IF=""4.0)

5.Wang Miao^(#), Liu Congcong^(#), Fan Qing^(#), Sun Yuehong^(#), Tang Shilong, Guo Huimin, Zhou Bing, Wang Haiyan, Ge Xiangyang, Zhang Zheng^(*), Ju Bin^(*). Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies . Journal of Immunology. 2025, 214(2):278-289. (IF=""4.2)

6.Ju Bin^(#), Zhang Qi^(#), Wang Ziyi^(#), Aw Zhen Qin^(#), Chen Peng^(#), Zhou Bing, Wang Ruoke, Ge Xiangyang, Lv Qining, Cheng Lin, Zhang Rui, Wong Yi Hao, Chen Huixin, Wang Haiyan, Shan Sisi, Liao Xuejiao, Shi Xuanling, Liu Lei, Chu Justin Jang Hann^(*), Wang Xinquan^(*), Zhang Zheng^(*), Zhang Linqi^(*). Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants . Nature Immunology, 2023, 24(4):690-699. (IF=""28.3)

7.Ju Bin^(#)(*), Fan Qing^(#), Liu Congcong^(#), Shen Senlin^(#), Wang Miao^(#), Guo Huimin, Zhou Bing, Ge Xiangyang, Zhang Zheng^(*). Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination . Cell Reports, 2023, 42(6):112532. (IF=""8.5)

8.Ju Bin^(#)(*), Fan Qing^(#), Wang Miao^(#), Liao Xuejiao, Guo Huimin, Wang Haiyan, Ge Xiangyang, Liu Lei, Zhang Zheng^(*). Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections . Nature Communications, 2022, 13(1):7120. (IF=""16.1)

9.Ju Bin^(#)(*), Zheng Qingbing^(#), Guo Huimin^(#), Fan Qing^(#), Li Tingting^(#), Song Shuo^(#), Sun Hui^(#), Shen Senlin, Zhou Xinrong, Xue Wenhui, Cui Lingyan, Zhou Bing, Li Shaowei^(*), Xia Ningshao^(*), Zhang Zheng^(*). Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209 . Cell Research, 2022, 32(5):491-494. (IF=""36.4)

10.Ju Bin^(#), Zhang Qi^(#), Ge Jiwan^(#), Wang Ruoke, Sun Jing, Ge Xiangyang, Yu Jiazhen, Shan Sisi, Zhou Bing, Song Shuo, Tang Xian, Yu Jinfang, Lan Jun, Yuan Jing, Wang Haiyan, Zhao Juanjuan, Zhang Shuye, Wang Youchun, Shi Xuanling, Liu Lei, Zhao Jincun, Wang Xinquan^(*), Zhang Zheng^(*), Zhang Linqi^(*). Human neutralizing antibodies elicited by SARS-CoV-2 infection . Nature, 2020, 584(7819):115-119. (IF=""54.4,"" C100, ESI)