个人简介

李子逸，研究员。2020年于北京大学获得博士学位，师从生物信息学专家张泽民院士，随后进入上海市免疫学研究所在Florent Ginhoux教授团队开展博士后工研究。

主要研究内容

课题组系统揭示了单核来源巨噬细胞与组织驻留巨噬细胞在肿瘤中的亚群组成与空间组织特征，证明了FOLR2+与SPP1+ TAM对 CSF1R 阻断具有不同敏感性（Cell 2020/2021，Nature Cancer 2023，Immunity 2024）。在耐药与复发机制研究中，我们在卵巢癌中证明内皮细胞及特定 DC 状态可提示铂类化疗敏感性；在肝细胞癌中鉴定出具有癌胚重编程特征的POSTN+ CAF，并发现其与 FOLR2+ TAM及PLVAP+内皮细胞共同构成的细胞微生态集群可驱动肿瘤早期复发，并影响Atezo-Bev联合免疫治疗的临床应答（Nature Cancer 2023/2024）。

代表性成果

1. Hu, Y.#, Wu, L., Qu, S., Kong, W. T., Yu, X., Xu, J., Xu, Z., He, J., Wang, C., Liu, Z., Lu, L., Ng, L. G., Blériot, C., Su, B., Ginhoux, F., Li, Z.*, and Chakarov, S*. (2026). Temporal and spatial atlas of eosinophil specialization across tissues. Nat Immunol . 27(2):364-375. (IF="27.6)

2. Guo, W.#, Li, Z.#, Anagnostopoulos, G., Kong, W.T., Zhang, S., Chakarov, S., Shin, A., Qian, J., Zhu, Y., Bai, W., Cexus, O., Nie, B., Wang, J., Hu, X., Bleriot, C., Liu, Z., Shen, B., Venteclef, N., Su, B*,and Ginhoux, F*. (2024). Notch signaling regulates macrophage-mediated inflammation in metabolic dysfunction-associated steatotic liver disease. Immunity . 57(10):2310-2327.e6. (IF="26.3)

3. Li, Z.#, Rhea, P., Saurabh, G., Jennifer, C., Wei, G., Anna, D., Hao, F., Zijie, Z., Zhizhen, L., Longqi, L., Abhishek, S., Yinqi, B., Bicheng, Y., Archita, M., Katharine, Y., Liang, Q., Michael, W., Yujia, Y., Qiang, X., Jerry, K., Jacob, G., Pierce, C.*, Florent, G.*, and Ankur, S*. (2024). Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy. Nat Cancer . 5(1):167-186. (IF="28.5)"

4. Zheng, X.#, Wang, X.#, Cheng, X.#, Liu, Z., Yin, Y., Li, X., Huang, Z., Wang, Z., Guo, W., Ginhoux, F., Li, Z.*, Zhang, Z.*, and Wang, X*. (2023). Single-cell analyses implicate ascites in remodeling the ecosystems of primary and metastatic tumors in ovarian cancer. Nat Cancer .4(8):1138-1156. (IF="23.5)"

5. Liu, Z.#*, Wang, H.#, Li, Z.#, Dress, R. J., Zhu, Y., Zhang, S., De Feo, D., Kong, W. T., Cai, P., Shin, A., Piot, C., Yu, J., Gu, Y., Zhang, M., Gao, C., Chen, L., Wang, H., Vetillard, M., Guermonprez, P., Kwok, I., Ng, L. G., Chakarov, S., Schlitzer, A., Becher, B., Dutertre, C. A., Su, B., and Ginhoux, F*. (2023). Dendritic cell type 3 arises from Ly6C(+) monocyte-dendritic cell progenitors. Immunity .56(8):1761-1777.e6. (IF="25.5," C100)

6. Cheng, S.#, Li, Z.#, Gao, R., Xing, B., Gao, Y., Yang, Y., Qin, S., Zhang, L., Ouyang, H., Du, P., Jiang, L., Zhang, B., Yang, Y., Wang, X., Ren, X., Bei, J., Hu, X., Bu, Z.*, Ji, J.*, and Zhang, Z*. (2021). A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells. Cell .184(3):792-809.e23. (IF="66.85," C100)

7. Zhang, L.#, Li, Z.#, Skrzypczynska, K.M.#, Fang, Q., Zhang, W., A. O’Brien, S., He, Y., Wang, L., Zhang, Q., Kim, A., Gao, R., Orf, J., Wang, T., Sawant, D., Kang, J., Bhatt, D., Lu, D., Li, C-M, Rapaport, A., Perez, K., Ye, Y., Wang, S., Hu, X., Ren, X., Ouyang, W., Shen, Z.*, Egen, J. G.*, Zhang, Z.*, and Yu, X*. (2020). Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Cell. 181(2):442-459.e29. (IF="41.582," C100)