个人简介

潘雨辰，研究员。2016和2021年分别在南开大学化学学院获得学士和博士学位。曾获京博优秀博士论文提名奖、天津市优秀博士论文等荣誉和奖励。 院校引进人才，2026年2月加入院校，曾在南开大学化学学院任博士后。

主要研究内容

一直从事超分子药物的研究工作，基于大环受体独特的三维立体结构和空腔载药模式，开发超强、选择性互作策略，设计合成高效识别的大环受体衍生物，从而实现对疾病靶点的高效干预和对药物分子的精准递送。目前，已经在Adv. Mater.、Angew. Chem. Int. Ed.、Acc. Chem. Res. 等期刊上发表学术论文30余篇，申请/授权国家发明专利7项，主持国家自然科学基金面上、青年（C类）等科研项目。

代表性成果

1. Yu-Chen Pan, Jia-Xuan Li, Dong-Sheng Guo*. The rise and promise of macrocyclic hosts in biomedicine. ACS Cent. Sci., 11(12): 2304-2318. (IF =" 10.4)

2. Ze-Han Wang^#, Yuan-Qiu Cheng^#, Wen-Bo Li, Meng-Meng Chen, Shu-Xin Zhang, Yu-Chen Pan*, Dong-Sheng Guo*. A study of chiral biomedical effects based on macrocyclic carriers. CCS Chem., 7(7): 2121-2136. (IF =" 9.2)

3. Qi-Yue Zhang^#, Qiang Wang^#, Jing-Xuan Fu, Xin-Xin Xu, Dong-Sheng Guo, Yu-Chen Pan*, Tao Zhang*, Hui Wang*. Multi targeted therapy for Alzheimer's disease by guanidinium-modified calixarene and cyclodextrin co-assembly loaded with insulin. ACS Nano, 18(48): 33032-33041. (IF =" 16.1)

4. Wen-Bo Li^#, Lin-Lin Xu^#, Si-Lei Wang, Ying-Yue Wang, Yu-Chen Pan*, Lin-Qi Shi*, Dong-Sheng Guo*. Co-assembled nanoparticles towards multi-target combinational therapy of Alzheimer's disease by making full use of molecular recognition and self-assembly. Adv. Mater., 36(28): 2401918. (IF = 26.8)

5. Yu-Chen Pan, Jia-Hong Tian, Dong-Sheng Guo*. Molecular recognition with macrocyclic receptors for application in precision medicine. Acc. Chem. Res., 56(24), 3626-33639. (IF = 16.7)

6. Yu-Chen Pan, Yu-Xin Yue, Xin-Yue Hu, Hua-Bin Li, Dong-Sheng Guo*. A supramolecular antidote to macromolecular toxins prepared through co-assembly of macrocyclic amphiphiles. Adv. Mater., 33(40): 2104310. (IF = 32.086)

7. Yu-Chen Pan, Andrea Barba-Bon, Han-Wen Tian, Fei Ding, Andreas Hennig, Werner M. Nau, Dong-Sheng Guo*. An amphiphilic sulfonatocalix[5]arene as a novel activator for membrane transport of lysine-rich peptides and proteins. Angew. Chem. Int. Ed., 60(4): 1875-1882. (IF =" 16.823)

8. Yu-Chen Pan, Xin-Yue Hu, Dong-Sheng Guo*. Biomedical applications of calixarenes: state-of-the-art and perspectives. Angew. Chem. Int. Ed., 60(6): 2768-2794. (IF = 16.823, C100)

9. Hui Wang^#, XinXin Xu^#, Yu-Chen Pan^#, YuXing Yan, Xin-Yue Hu, RunWen Chen, Bart Jan Ravoo, Dong-Sheng Guo*, Tao Zhang*. Recognition and removal of amyloid-b by a heteromultivalent macrocyclic coassembly: a potential strategy for the treatment of Alzheimer's disease. Adv. Mater., 33(4): 2006483. (IF = 32.086)

10. Yu-Chen Pan^#, Hui Wang^#, Xinxin Xu^#, Han-Wen Tian, Hong Zhao, Xin-Yue Hu, Yu Zhao, Yang Liu, Guihua Ding, Qingbin Meng, Bart Jan Ravoo, Tao Zhang*, Dong-Sheng Guo*. Coassembly of macrocyclic amphiphiles for anti-β-amyloid therapy of Alzheimer's disease. CCS Chem., 3(9): 2485-2497. (IF = 9.2)