个人简介

周青，教授，博士生导师，研究自身炎症性疾病。2009年博士毕业于中国科学院北京基因组所，2010年至2017年在美国国立人类基因组研究所任博士后，研究人员，临床分子遗传诊断人员。获得美国国立卫生研究院FARE Award、Orloff Science Award、GREAT Award，国际自身炎症疾病学会Young Investigator Award，求是科技基金会求是杰出青年学者奖，中国细胞生物学学会青年女科学家职业发展奖A项奖，中源协和第六届生命医学创新突破奖，国家自然科学基金国家杰出青年，新基石科学基金会科学探索奖等。院校引进人才，2026年加入院校，曾在浙江大学生命科学研究院任求是特聘教授。

主要研究内容

长期从事自身炎症性疾病的研究，发现并命名9种新自身炎症性疾病，包括CRIA，PLDD，DADA2，LIRSA，HA20，Otulipenia，APLS，APLAID，AP1M2 deficiency。研究发现自身炎症性疾病的新致病基因，包括RIPK1，PLD4，ADA2，IL1R1，TNFAIP3，OTULIN，PLCG1，PLCG2，AP1M2和体细胞NLRP3、NLRC4、TLR7突变等。深入研究自身炎症性疾病致病机制，首次报道细胞死亡和去泛素化缺陷可导致自身炎症性疾病。基于研究成果转化临床应用，根据致病机制探索靶向治疗方案，成功治疗7种自身炎症性疾病。 通讯作者（并列）文章40篇，发表在Nature (2020,2025)，Immunity，Annals of the Rheumatic Diseases (2022, 2025a, 2025b)，Nature Communications (2026a, 2026b)，Journal of Allergy and Clinical Immunology (2022, 2023, 2026)，Arthritis and Rheumatology (2022, 2024, 2025, 2026a, 2026b)，Journal of The American Society of Nephrology，Annual Review of Genetics, Science Advances，Proceedings of the National Academy of Sciences等学术期刊。第一作者（并列）文章13篇，发表在The New England of Journal Medicine，Nature Genetics，Proceedings of the National Academy of Sciences，American Journal of Human Genetics，Arthritis and Rheumatism等学术期刊。

代表性成果

1. Qintao Wang, Honghao Zhu, Xiangwei Sun, Changming Zhang, Shuangyue Ma, Ying Jin, Jinjian Fu, Chenlu Liu, Jiahui Peng, Ruoran Wang, Lin Liu, Yi Zeng, Cheng Gong, Qing Zhou#, Xiaomin Yu#, Zhihong Liu#. Loss-of-function mutations in PLD4 lead to systemic lupus erythematosus. Nature 2025. doi: 10.1038/s41586-025-09513-x.

2. Panfeng Tao, Jinqiao Sun, Zheming Wu, Shihao Wang, Jun Wang, Wanjin Li, Heling Pan, Renkui Bai, Jiahui Zhang, Ying Wang, Pui Y Lee, Wenjing Ying, Qinhua Zhou, Jia Hou, Wenjie Wang, Bijun Sun, Mi Yang, Danru Liu, Ran Fang, Huan Han, Zhaohui Yang, Xin Huang, Haibo Li, Natalie Deuitch, Yuan Zhang, Dilan Dissanayake, Katrina Haude, Kirsty McWalter, Chelsea Roadhouse, Jennifer J MacKenzie, Ronald M Laxer, Ivona Aksentijevich, Xiaomin Yu#, Xiaochuan Wang#, Junying Yuan#, Qing Zhou#. A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature 2020 Jan;577(7788):109-114.

3. Yusha Wang, Jun Wang, Wenjie Zheng, Jiahui Zhang, Jinbo Wang, Taijie Jin, Panfeng Tao, Yibo Wang, Chenlu Liu, Jiqian Huang, Pui Y. Lee, Xiaomin Yu#, Qing Zhou#. Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design. Immunity 2023 Jul 11;56(7):1485-1501.

4. Lin Liu, Jun Wang, Yan Ding, Li Guo, Mikhail Kostik, Meiping Lu, Yudie Fei, Xiangwei Sun, Yi Zeng, Yusha Wang, Qian Ma, Yang Liu, Xinghui Yang, Yali Wu, Bin Zhu, Xiangmin Tong, Xiaomin Yu#, Qing Zhou#. TBXAS1 deficiency causes autoinflammation responsive to IL-6 inhibitor. Annals of the Rheumatic Diseases 2025 Oct 28:S0003-4967(25)04428-0.

5. Yi Zeng, Panfeng Tao, Jun Wang, Ting Li, Yue Du, Xiuli Wang, Wei Wang, Siming Peng, Wei Wang, Mingsheng Ma, Hongmei Song#, Xiaomin Yu#, Qing Zhou#. Somatic gain-of-function mutation in TLR7 causes early-onset systemic lupus erythematosus. Annals of the Rheumatic Diseases 2025 Mar;84(3):442-450.

6. Jun Wang, Qiao Ye, Wenjie Zheng, Xiaomin Yu, Fang Luo, Ran Fang, Yaoyao Shangguan, Zhijun Du, Pui Y Lee, Taijie Jin#, Qing Zhou#. Low-ratio somatic NLRC4 mutation causes late-onset autoinflammatory disease. Annals of the Rheumatic Diseases 2022 Aug;81(8):1173-1178.

7. Jialin Dai, Taijie Jin, Gaixiu Su, Xu Han, Jun Wang, Chenlu Liu, Wenjie Zheng, Qiuye Zhang, Ranran Zhang, Hye Sun Kuehn, Jun Yang, Li Guo, Dan Zhang, Ming Li, Yingjie Xu, Tong Yue, Min Wen, Jia Zhu, Min Kang, Jianming Lai, Feifei Wu, Shihao Wang, Jiahui Zhang, Ivona Aksentijevich, Sergio D Rosenzweig, Pui Y Lee, Junying Yuan#, Xiaomin Yu#, Qing Zhou#. CD8+ T cell loss induces autoinflammation in inborn errors of cell death. Nature Communications 2026 Mar 11.doi: 10.1038/s41467-026-70317-2.

8. Natalie T Deuitch#, Dan Yang, Pui Y Lee, Xiaomin Yu, ..., Daniel L Kastner, Ivona Aksentijevich#, Qing Zhou#. TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2). Journal of Allergy and Clinical Immunology 2022 May;149(5):1812-1816.e6.

9. Jinjian Fu, Qiong Fu, Jun Wang, Qintao Wang, Liang Zhang, Huihui Chi, Lei Zhang, Li Sun, Ying Huang, Tingyan He, Yuhao Yao, Xu Han, Shuangyue Ma, Chenlu Liu, Lin Liu, Xiang Chen, Shihao Wang, Hong Jiang, Wenjie Zheng, Shaoling Zheng, Qiao Ye, Yue Du, Li Guo, Jing Zhu, Guomin Li, Changming Zhang, Zhimiao Lin, Xiuli Ju, Yongmei Han, Weiqian Chen, Jin Lin, Jing Xue, Hao Cheng, Caiqing Xu, Lin Huang, Longyan Qin, Jiashun Zeng, Yifang Mei, Tingting Yan, Qianying Lv, Yaoyao Shangguan, Cuifang Zheng, Xiaoliang He, Hongfei Liu, Xiaoli Chen, Hua Xie, Xue Li, Ying Jin, Jiahui Peng, Bo Lin, Yao Huang, Xiuli Wang, Xiaoxi Yang, Nan Jiang, Wei Wang, Tong Wu, Dongze Wu, Yun Zhu, Yakai Fu, Jie Chen, Ran Wang, Xiaojun Liu, Dongbin Jiang, Huijie Xiao, Baige Su, Benshan Zhang, Fengqi Wu, Qiongyi Hu, Chengde Yang, Meiping Lu, Shuang Ye, Min Shen, Hongmei Song#, Jianghua Chen#, Jun Yang#, Zhihong Liu#, Xiaomin Yu#, Qing Zhou#. Landscape of somatic mutations in a large cohort of Chinese patients with immune dysregulations. Arthritis & Rheumatology 2026 Mar 9. doi: 10.1002/art.70126.

10. Taijie Ji, Jialin Dai, Chenlu Liu, Renkui Ba, …, Xiaomin Yu#, Qing Zhou#. Deficiency of AP1M2 causes a new autoinflammatory disease with colitis. Arthritis & Rheumatology 2025 Dec 26. doi: 10.1002/art.70038.